Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells.
Identifieur interne : 001895 ( Main/Exploration ); précédent : 001894; suivant : 001896Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells.
Auteurs : R A Nicoll ; B E AlgerSource :
- Science (New York, N.Y.) [ 0036-8075 ] ; 1981.
Descripteurs français
- KwdFr :
- Animaux, Bicuculline (pharmacologie), Calcium (pharmacologie), Conductivité électrique, Glutamates (pharmacologie), Hippocampe (physiologie), Inhibition nerveuse (), Potassium (physiologie), Potentiels de membrane (), Rats, Stimulation électrique, Techniques in vitro, Tractus pyramidaux (physiologie), Transmission synaptique.
- MESH :
- pharmacologie : Bicuculline, Calcium, Glutamates.
- physiologie : Hippocampe, Potassium, Tractus pyramidaux.
- Animaux, Conductivité électrique, Inhibition nerveuse, Potentiels de membrane, Rats, Stimulation électrique, Techniques in vitro, Transmission synaptique.
English descriptors
- KwdEn :
- Animals, Bicuculline (pharmacology), Calcium (pharmacology), Electric Conductivity, Electric Stimulation, Glutamates (pharmacology), Hippocampus (physiology), In Vitro Techniques, Membrane Potentials (drug effects), Neural Inhibition (drug effects), Potassium (physiology), Pyramidal Tracts (physiology), Rats, Synaptic Transmission.
- MESH :
- chemical , pharmacology : Bicuculline, Calcium, Glutamates.
- drug effects : Membrane Potentials, Neural Inhibition.
- physiology : Hippocampus, Potassium, Pyramidal Tracts.
- Animals, Electric Conductivity, Electric Stimulation, In Vitro Techniques, Rats, Synaptic Transmission.
Abstract
In hippocampal CAl pyramidal cells, orthodromic synaptic excitation is followed by an early hyperpolarization mediated by gamma-aminobutyric acid (GABA) and a late non-GABA-mediated hyperpolarization that has properties consistent with an increase in potassium conductance. Depolarizations produced by iontophoretically applied glutamate are followed by hyperpolarizations that have features in accordance with an increase in potassium conductance. The hyperpolarizations are independent of chloride and resistant to tetradotoxin but are blocked by a low-calcium, high-cobalt medium. Voltage clamping the glutamate depolarization does not reduce the subsequent hyperpolarization, indicating that the hyperpolarization results from a direct increase in calcium conductance produced by glutamate, rather than from activation of voltage-sensitive calcium channels. A single transmitter, possibly acting on one type of receptor and channel, may initiate both excitation and inhibition in the same postsynaptic cell.
PubMed: 6262912
Affiliations:
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Le document en format XML
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Depolarizations produced by iontophoretically applied glutamate are followed by hyperpolarizations that have features in accordance with an increase in potassium conductance. The hyperpolarizations are independent of chloride and resistant to tetradotoxin but are blocked by a low-calcium, high-cobalt medium. Voltage clamping the glutamate depolarization does not reduce the subsequent hyperpolarization, indicating that the hyperpolarization results from a direct increase in calcium conductance produced by glutamate, rather than from activation of voltage-sensitive calcium channels. A single transmitter, possibly acting on one type of receptor and channel, may initiate both excitation and inhibition in the same postsynaptic cell.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Alger, B E" sort="Alger, B E" uniqKey="Alger B" first="B E" last="Alger">B E Alger</name><name sortKey="Nicoll, R A" sort="Nicoll, R A" uniqKey="Nicoll R" first="R A" last="Nicoll">R A Nicoll</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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